Environmental agents, oxidative stress and autoimmunity

Oxidative Stress, Altered-Self and Autoimmunity

It is well known that oxidative stress can induce production of free radicals that can modify proteins. The hypothesis presented here is that the target antigens in autoimmune diseases, such as type 1 diabetes mellitus, are not normal self proteins but rather self proteins that have been altered by free radicals, produced as a result of oxidative stress in the target cells. The observation that...

Oxidative Stress – Environmental Induction

Environmental Pollution and Oxidative Stress in Fish

Living systems encounter a variety of stresses during their continuous interaction with environment. Environmentally-induced stresses frequently activate the endogenous production of reactive oxygen species (ROS), most of which are generated as side products of tissue respiration. Hence, constant exposure to stressors may enhance ROS-mediated oxidative damage. Increased number of agricultural a...

Environmental Triggers and Autoimmunity

Currently, studies have shown that genetic predisposition accounts for approximately thirty percent of all autoimmune diseases. The rest, 70 percent, are due to environmental factors, including toxic chemicals, dietary components, gut dysbiosis, and infections (Figure 1). Autoimmune disorder symptoms are initially nonspecific and include malaise and fatigue, low-grade fevers, aches, and pains. ...

Exposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress

Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...